Diffusion of a disordered protein on its folded ligand

Flexibility in complexes between intrinsically disordered proteins and folded ligands is widespread nature. However, timescales spatial amplitudes of such dynamics remained unexplored for most systems. Here, we directly measure the an exceptionally mobile, high-affinity complex. We show that tail cell adhesion protein E-cadherin dynamically samples a large surface area protooncogene ?-catenin. Single-molecule experiments molecular simulations resolve these motions with high resolution space time.